Last edited by Faujind
Sunday, April 26, 2020 | History

6 edition of Drug-induced mitochondrial dysfunction found in the catalog.

Drug-induced mitochondrial dysfunction

Drug-induced mitochondrial dysfunction

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  • 39 Currently reading

Published by J. Wiley in Hoboken, N.J .
Written in English

    Subjects:
  • Drugs -- Toxicology,
  • Mitochondrial pathology,
  • Mitochondrial Diseases -- chemically induced,
  • Mitochondria -- drug effects,
  • Mitochondria -- physiology

  • Edition Notes

    Includes bibliographical references and index.

    Statement[edited by] James Dykens, Yvonne Will.
    ContributionsDykens, James., Will, Yvonne.
    Classifications
    LC ClassificationsRA1238 .D783 2008
    The Physical Object
    Paginationp. ;
    ID Numbers
    Open LibraryOL16474530M
    ISBN 109780470111314
    LC Control Number2008002720

    Mitochondrial disease and toxicity is a rapidly advancing field and the consequences of mitochondrial impairment should be appreciated by scientists in all disciplines. Numerous widely prescribed therapeutics can undermine mitochondrial function by interfering with DNA replication or expression, and more acutely, by uncoupling or inhibiting.


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Drug-induced mitochondrial dysfunction Download PDF EPUB FB2

Drug and Environmental Induced Mitochondrial Dysfunction provides ample reminders of the intimate connections between mitochondria, pharmacology, and toxicology.

The book takes a rather systematic approach to mitochondrial pharmacology and toxicology and, for this reason, will be of use to even those outside of strict drug : Yvonne Will. About this book.

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. Dykens has published extensively on drug-induced mitochondrial dysfunction, on the role of mitochondrial free radical production in the etiology of.

Drug-Induced Mitochondrial Dysfunction - Kindle edition by Dykens, James A., Will, Yvonne. Download it once and read it on your Kindle device, PC, phones Drug-induced mitochondrial dysfunction book tablets.

Use features like bookmarks, note taking and highlighting while reading Drug-Induced Mitochondrial Dysfunction.5/5(3). Mitochondrial DNA as a Potential Translational Biomarker of Mitochondrial Dysfunction in Drug‐Induced Toxicity Studies (Pages: ) Afshan N. Malik Summary. Get this from a library.

Drug-induced mitochondrial Drug-induced mitochondrial dysfunction book. [James Alan Dykens; Yvonne Will;] -- A resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process.

It discusses mitochondrial impairment to organs, skeletal. Book. Drug-Induced Mitochondrial Dysfunction This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in.

Clinical Assessment of Mitochondrial Function via [13 C]Methionine Exhalation (Laura Milazzo). Assessment of Mitochondrial Dysfunction by Microscopy (Ingrid Pruimboom-Brees, Germaine Boucher, Amy Jakowski, and Jeanne Wolfgang). Drug-induced mitochondrial dysfunction book Development of Animal Models of Drug-Induced Mitochondrial Toxicity (Urs A.

Drug-induced mitochondrial dysfunction book and Yie Hou Lee). Price: $ Drug-Induced Mitochondrial Dysfunction - Ebook written by James A.

Dykens, Yvonne Will. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you 1/5(1). Mitochondrial function declines with age, leading to a variety of age-related diseases (metabolic, central nervous system-related, cancer, etc.) and medication usage increases with age due to the increase in diseases.

Drug-induced mitochondrial toxicity has been described for many different drug classes and can lead to liver, muscle, kidney and central nervous system injury and, in Cited by: 2.

3. Drug-Induced Mitochondrial Toxicity. Drug-induced mitochondrial toxicity has been studied in academic settings for well over 50 years. Indeed, many such studies relied on xenobiotic inhibitors, such as rotenone, antimycin and oligomycin, to deduce the function of the ETC, and uncouplers such as 2,4 dinitrophenol, to understand how mitochondria generate by: 2.

Dr. Dykens has published Drug-induced mitochondrial dysfunction book on drug-induced mitochondrial dysfunction, on the role of mitochondrial free radical production in the Drug-induced mitochondrial dysfunction book of neurodegenerative diseases, and on the physiological ecology of marine symbioses.

Yvonne Will, PhD, works in Pfizer's Exploratory Safety Differentiation Group in Groton, Connecticut. This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, Drug-induced mitochondrial dysfunction book the issue upfront in the drug development process.

It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and. Developed as Drug-induced mitochondrial dysfunction book one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided.

Covers both basic science and applied technology / methods Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what Drug-induced mitochondrial dysfunction book reveal about.

With chapters contributed by leading specialists in their Drug-induced mitochondrial dysfunction book, Drug-Induced Mitochondrial Dysfunction: Explains basic concepts so that non-specialists can understand mitochondrial function.

Discusses mitochondrial etiology of organ toxicity, covering the liver, heart, and kidney, as well as the skeletal muscle, nervous system, and lipoatrophy5/5(2). Mitochondrial dysfunction is a major mechanism whereby different drugs can induce liver injury such as cytolytic hepatitis, microvesicular and/or macrovacuolar steatosis, steatohepatitis, and.

MitoAction is excited to welcome Dr. James Dykens, Director of Investigative Cellular Toxicity at Pfizer Drug Safety Research & Development and author of the book “Drug Induced Mitochondrial Dysfunction”. Dykens shares with us today his perspectives on the relationship of mitochondrial function to overall health and discusses the potential effects of potential drug.

Any of my search term words; All of my search term words; Find results in Content titles and body; Content titles only. Buy the Hardcover Book Drug-Induced Mitochondrial Dysfunction by James A. Dykens atCanada's largest bookstore. Free shipping and pickup in store on eligible orders.

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process.

Acquired mitochondrial disorders occur more commonly during adulthood due to insufficient nutrients, drug-induced toxicity, high levels of inflammation and oxidative stress, environmental toxins like mercury and arsenic, and poorly managed blood sugar.

Many symptoms are related to diminished mitochondria function. Medication-induced mitochondrial damage and disease. Neustadt J(1), Pieczenik SR. Author information: (1)Montana Integrative Medicine, Bozeman, MTUSA.

[email protected] Since the first mitochondrial dysfunction was described in the s, the medicine has advanced in its understanding the role mitochondria play in health and by:   Mitochondrial dysfunction can be a major mechanism whereby different drugs can induce adverse effects affecting different tissues such as liver, heart and skeletal muscle.

In the most severe cases, drug-induced mitochondrial dysfunction can require a hospitalization, or lead to the death of the by: 1. Introduction. Steatosis, also referred to as fatty liver, is a hepatic lesion that can be frequently induced by ethanol overconsumption and many xenobiotics, such as drugs and environmental pollutants.1, 2, 3 Notably, fat accumulation in the liver (mainly as triglycerides) is also present in a majority of obese individuals, even in those who are not drinking alcohol or are unexposed to Cited by: 1.

In some patients, infections and cytokines, or inborn errors of β-oxidation enzymes or the mitochondrial genome, may favor the appearance of drug-induced microvesicular steatosis.

Nonalcoholic steatohepatitis may develop under conditions causing prolonged, microvesicular and/or macrovacuolar : B. Fromenty, C. Maisonneuve, A. Berson, D.

Pessayre. Organization and genomics. Also considered as a reticulum, the mitochondrial network continuously moves, fuses and divides in a process tightly regulated by cellular stimuli and disturbances inside this organelle (Detmer & Chan, ).The shape greatly varies depending on the tissue, developmental and physiological state.

Within a cell, the distribution of mitochondria Cited by: 5. Drug-Induced Liver Disease, 3 rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more.

Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the. this book may not be available in other formats.

Title: Mitochondrial dysfunction caused by drugs and environmental toxicants / edited by Yvonne Will, James A. Dykens. 5 Mitochondrial Dysfunction in Drug‐Induced Liver Injury 49 Annie Borgne‐Sanchez and Bernard Fromenty. Mitochondrial dysfunction, axonal transport deficits, and SNCA aggregation may participate in a self-perpetuating cycle of neuron damage in PD [].

Leucine-rich repeat kinase 2 (LRRK2) LRRK2 is a amino acid protein that contains functional kinase and guanosine triphosphate (GTP) as domains, and leucine-rich repeat and WD40 protein Cited by: 2. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants.

Volume I and II. John Wiley& Sons Inc, New York, NY. Dykens and Y. Will, (Editors) Drug induced mitochondrial Toxicities. John Wiley& Sons Inc, New York, NY. Review Articles: James Hynes and Yvonne Will. The Evolution of Mitochondrial Toxicity Assessment in Industry.

Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible.

Drug-induced cardiovascular toxicity is thought to be mediated by mitochondrial dysfunction. 1 Mitophagy is a process of recovery through which damaged mitochondria are removed.

2 Recurrent mitochondrial toxicity secondary to drug and radiation therapy can overcome mitophagy and lead to sustained mitochondrial dysfunction. 3 In this review, we. In recent decades, increasing number of studies have reported alterations in Mitochondrial DNA (MtDNA) in a large number of human diseases, and levels of MtDNA in body fluids and tissues are being used as an indicator of mitochondrial damage in cross-sectional and longitudinal human studies, leading to the hypothesis that MtDNA changes may be utilised as a biomarker of Author: Afshan Navid Malik.

Abstract. Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds.

These compounds stimulate the development of steatohepatitis through their toxicity to hepatocyte mitochondria; inhibition of beta-oxidation, mitochondrial respiration, and/or oxidative phosphorylation. Some companies will focus more on investigating direct drug-induced mitochondrial dysfunction, others will rather measure drug-induced alterations in mitochondrial-relevant genes.

Whatever the chosen strategy is, the final outcome is the prediction Cited by: 2. @article{osti_, title = {Assessment of mitochondrial dysfunction-related, drug-induced hepatotoxicity in primary rat hepatocytes}, author = {Liu, Cong and Sekine, Shuichi and Ito, Kousei}, abstractNote = {Evidence that mitochondrial dysfunction plays a central role in drug-induced liver injury is rapidly accumulating.

In contrast to physiological conditions, in which. Drug-induced mitochondrial toxicity has been described for many different drug classes and can lead to liver, muscle, kidney and central nervous system injury and, in rare cases, to death.

Many of the most prescribed medications in the. The two referred examples result in important take-home messages: a) drug-induced cardiac mitochondrial dysfunction is an important contributor for drug-associated organ failure, b) protection of mitochondrial function is involved in the beneficial impact of some clinically-used drugs and c) a more accurate prediction of toxic vs.

beneficial. Drug-Induced Mitochondrial Dysfunction è un libro di Dykens James A. (Curatore), Will Yvonne (Curatore) edito da John Wiley & Sons a ottobre - EAN puoi acquistarlo sul sitola grande libreria online. This article describes the mechanisms which lead to drug-induced mitochondrial toxicity, discusses high-throughput in vitro assays which are currently being used to identify mitochondrial dysfunction, and provides an overview on some of the drugs which impair mitochondrial function.

Original language: English (US) Title of host publication: Drug-Induced Mitochondrial Dysfunction: Publisher: John Wiley & Sons, Inc. Pages: Number of pagesAuthor: Paulo J. Oliveira, Vilma A. Sardão, Kendall B. Wallace. A report ‘Drug-Induced Mitochondrial Dysfunction: An Emerging Model for Idiosyncratic Drug Toxicity’ by James A.

Dykens of Pfizer Drug Safety Research & Development 4 is a comprehensive look at numerous medications including some that may be used on children including certain antibiotics or antivirals that have black box warnings.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants Yvonne Will, James A. Pdf Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in .We combined mitochondrial and cellular assays to predict drug-induced mitochondrial dysfunction in liver.

Extensive screening of reference compounds on isolated liver mitochondria revealed a highly significant relationship between acute mitochondrial toxicity detected by this system and DILI occurrence in human.

The Ebook. All classes of psychotropic drugs have documented toxic mitochondrial effects. Many of which block key enzymes in the electron transport chain of the mitochondria. Statin drugs completely block the enzyme HMG-CoA reductase, which severely inhibits CoQ10 production—a necessary nutrient for mitochondrial function.

As another .